Imad Matouk

Post:

Assistant Professor 

Location:

Department of biology, Faculty of and Science, Al-Quds university,  Jerusalem, Palestine

Email:

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Telephone numbers

 

Internal:

-

Palestine:

-

International:

-

Mobile:

00972541404169

 

About

  • Researcher in the field of cancer molecular biology.
  • Educated in Hadasah Medical School (PhD),
  • Hebrew University (MSC)
  • (BSC) at Birzeit University of Palestine.  

Research interests

  • The role of lncRNA genes in tumorigenesis.
  • MicroRNAs roles in cancer.
  • The role of hypoxia in cancer progression and metastasis.
  • Gene therapy of cancer.

 

Teaching activities

  • Genetics.
  • Cell biology.
  • Molecular biology.
  • The biology of cancer.
  • Genetic engineering and biotechnology.
  • Gene therapy.
  • Introduction to biological science.

Selected publications

  • Matouk I,Ayesh S, Schnieder T, Ohana P, Lester M, Al-Sharef W, de Groot N and. Hochberg A (2002). The possible physiological role of H19 RNA. Mol. Carcinogenesis. 35 63-74.
  • Matouk I,  Ayesh B,  Schneider T,  Ohana P,  de Groot N,  Hochberg A and  Galun E. (2004) Oncofetal slice-pattern of human H19 Gene. Biochem Biophys Res Commun. 318 916-919.
  • Matouk I,  DeGRoot N,  Hochberg A.  Galun E. (2007) The H19 non-coding RNA is esssential for human tumor growth.PloS ONE e854.
  • Matouk I,  Ohana P,  Ayesh A,  Sidi A,  Czerniak A,. de Groot N, and  Hochberg A (2005). The oncofetal H19 RNA in human cancer from the bench to the patient. Gene Ther. & Mol. Biol.  3, 249-266.
  • Banet G,  Bibi O,  Matouk I, Ayesh S,  Lester M,  Molner-Kimber K, Tykocinski M,  de Groot N,  Hochberg A and  Ohana P. (2001) Characterization of human and mouse H19 regulatory sequences. Mol. Biol. Rep. 27, 157-165.
  • Abdul-Ghani R, Ohana P, Matouk I,  Ayesh S, Laster M,  Bibi O,  Giladi H, K. Molnar-Kimber, de Groot N,  Hochberg A. (2000)  Use of transcriptional regulatory sequences of telomerase (hTER and hTERT) for selected killing of cancer cells. Mol. Therapy 2, 539-544 .
  • Ohana P,Bibi O  Matouk I,. Levi C,  Berman T,  Ariel I,  Schneider T,  Ayesh S,  Giladi H,  de Groot  N and  Hochberg A. (2002) The use of H19 regulatory sequences for targeted therapy in cancer. Int. J. of Cancer. 98 645-650.
  • Ayesh B,  Matouk I,  Ohana P,  Sughayer MA,  Birman T,  Ayesh S, N. de Groot and  Hochberg A. (2003) Inhibition of tumor growth by DT-A expressed under the control of IGF2 P3 and P4 promoter sequences. Mol. Therapy 7 535-541 (2003).
  • Ohana P,  Gofrit O,  Ayesh S,  Al-Sharef W, Mizrahi A,  Birman T,  Schneider T,  Matouk I, N. de Groot,  Tavdy E,  Sidi A and Hochberg A.(2004). Regulatory sequences of H19 gene in DNA based therapy of bladder cancer. Gene therapy and molecular biology. 8 233-234 .
  • Ohana P,  Schachter P,  Ayesh B,  Mizrachi A,  Birman T,  Schneider T,  Matouk I, P.Y Kuppen, N. de Groot,  Czerniak A and Hochberg A. (2004) Regulatory sequences of H19 and IGF2 genes in DNA based therapy of colorectal rat liver metases. J. of Gene. Medicine. 7:366-74.
  • Sorin V, Ohana P, Gallula J, Birman T, Matouk I, Hubert A, Gilon M, Hochberg A, Czerniak A.(2012) H19-promoter-targeted therapy combined with gemcitabine in the treatment of pancreatic cancer. ISRN Oncol. 351750.
  • Amit D, Matouk IJ, Lavon I, Birman T, Galula J, Abu-Lail R, Schneider T, Siegal T, Hochberg A, Fellig Y. (2012)Transcriptional targeting of glioblastoma by diphtheria toxin-A driven by both H19 and IGF2-P4 promoters. Int J Clin Exp Med. 5:124-35.
  • Sorin V, Ohana P, Mizrahi A, Matouk I, Birman T, Hochberg A, Czerniak A. (2011) Regional therapy with DTA-H19 vector suppresses growth of colon adenocarcinoma metastases in the rat liver. Int J Oncol. 39: 1407-12.
  • Mizrahi A, Hochberg A, Amiur S, Gallula J, Matouk I, Birman T, Levy T, Ladimir S, Ohana P. (2010) Targeting diphtheria toxin and TNF alpha expression in ovarian tumors using the H19 regulatory sequences. Int J Clin Exp Med. 3:270-82.
  • Mizrahi A, Czerniak A, Ohana P, Amiur S, Gallula J, Matouk I, Abu-Lail R, Birman T, Hochberg A, Levy T (2010). Treatment of ovarian cancer ascites by intra-peritoneal injection of diphtheria toxin A chain-H19 vector: a case report. J Med Case Rep.  27;4:22.
  • Matouk IJ, Mezan S, Mizrahi A, Ohana P, Abu-Lail R, Fellig Y, Degroot N, Galun E, Hochberg A. The oncofetal H19 RNA connection: hypoxia, p53 and cancer. Biochim Biophys Acta. 1803:443-51.
  • Mizrahi A, Czerniak A, Levy T, Amiur S, Gallula J, Matouk I, Abu-lail R, Sorin V, Birman T, de Groot N, Hochberg A, Ohana P. (2009) Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences. J Transl Med. 6;7:69.
  • Matouk IJ, Abbasi I, Hochberg A, Galun E, Dweik H, Akkawi M. (2009) Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis. Eur J Gastroenterol Hepatol. 21: 688-92.
  • Matouk IJ, Ohana P, Galun E, Hochberg A. (2008). The pivotal role of the oncofetal H19 RNA in human cancer, a new hope. Gene Therapy and Cancer Research Trends   Nova Publishers .
  • Fellig Y, Amit D, Matouk IJ, Kopolovic J, Erdmann VA, Hochberg A. (2009). The Non-Coding Oncofetal H19 Gene in Brain Tumors. Therapeutic Ribonucleic Acids in Brain Tumors pp 471-484. Springer Berlin Heidelberg.
  • Matouk IJ, Amit D, Ohana P, et al. The H19-IGF2 role in bladder cancer biology and DNA-based therapy. Bladder cancer: From basic science to robotic surgery. InTech 363-380 (2012).
  • Akkawi M, Abasi I, Hochberg A, Gofrit O, Dweik H and Matouk I. (2006) The human VG5Q gene transcript is overexpressed in colorectal and bladder carcinomas. Gene Ther Mol Biol. 10, 173-78 .
  • Imad Matouk ,Eli Raveh, Patrecia Ohana, Rasha Abu-lail, Eitan Gershtain, Michal Gilon, Abraham Hochberg; The Increasing Complexity of the Oncofetal H19 Gene Locus: Functional Dissection and Therapeutic Intervention Int. J. Mol. Sci. 2013, 14(2), 4298-4316 ,February 21, 2013.
  • Amit D, Gofrit ON, Matouk I, Birman T, Hochberg A . Use of preclinical models to assess the therapeutic potential of new drug candidates for bladder cancer. Semin Oncol. 2012 Oct;39(5):534-42.
  • Sohn YS, Tamir S, Song L, Michaeli D, Matouk I, Conlan AR, Harir Y, Holt SH, Shulaev V, Paddock ML, Hochberg A, Cabanchick IZ, Onuchic JN, Jennings PA, Nechushtai R, Mittler R. NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14676-81.
  • Matouk IJ, Raveh E, Abu-lail R, Mezan S, Gilon M, Gershtain E, Birman T, Gallula J, Schneider T, Barkali M, Richler C, Fellig Y, Sorin V, Hubert A, Hochberg A, Czerniak A. Oncofetal H19 RNA promotes tumor metastasis. Biochim Biophys Acta. 2014 Jul;1843(7):1414-26.
  • Matouk IJ, Halle D, Gilon M, Hochberg A. The non-coding RNAs of the H19-IGF2 imprinted loci: a focus on biological roles and therapeutic potential in Lung Cancer. J Transl Med. 2015 Apr 9;13:113.
  • Abbasi Ibrahim, Al-Shareef Abdel-Kareem, Matouk Imad, Akkawi Muataz. Development of a PCR/RLB Test for Meat Source Authentication in Processed Meat and Meat Products. Turkish Journal of Agriculture - Food Science and Technology, 3(4): 216-220, 2015.