Rafik Karaman

Post:

Lecturer at Faculty of Pharmacy

Location:

Faculty of Pharmacy, Al-Quds University, Jerusalem, Palestine

Email:

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Telephone numbers

 

Internal:

 

Palestine:

02-2790413

International:

00972-02-2790413

Fax:

00972-02-2790413

 

About

Education:

  • 1981 The Hebrew University, School of Pharmacy, Jerusalem, B.Sc. Pharm.
  • 1983 The Hebrew University, School of Pharmacy, Jerusalem, M.Sc. Pharm. (Honor).
    • Title of thesis: “Quantitative Structure Activity Relationship between β- Glucoronides and the Enzyme β- Glucoronidase”.
    • Supervisor: Prof. Amiram Goldblum.
  • 1987 The Hebrew University, School of Pharmacy, Department of Bioorganic Chemistry, Jerusalem, Ph.D. (Honor).
    • Title of Thesis:” Synthesis, Characterization and Physical Properties of Acylphosphonic Acids and their Oxyimino Derivatives:
    • Supervisors: Prof. Eli Breuer and Prof. Amiram Goldblum.
  • 1988 Department of Chemistry, the University of Toledo, Ohio, USA
    • Assistant Professor, Bioorganic Chemistry.
  • 1990 Department of Chemistry, the University of California at Santa Barbra (UCSB), Santa Barbra, California, USA
    • Assistant Professor, Bioorganic Chemistry.
  • 1992 Distinguished Scientist, Bioorganic Chemistry (UCSB), Santa Barbra, California, USA
  • 1994 Eastern Pharmaceutical Company, Ramallah, Palestine, CEO.
  • 2005- 2010 College of Pharmacy, Al-Quds University, Abu-Dies, Jerusalem,Palestine.
    • Associate Professor, Bioorganic Chemistry.
  • 2010-2013 College of Pharmacy, Al-Quds University, Abu-Dies, Jerusalem, Palestine.
    • Professor, Bioorganic Chemistry.
  • 2013-present College of Pharmacy, Al-Quds University, Abu-Dies, Jerusalem, Palestine.
    • Distinguished Professor, Bioorganic Chemistry.
  • 2013-present Basilicata University, College of Sciences, Potenza, Italy
    • Adjunct Professor.

Experience

  • 1981-1986 the Hebrew University, School of Pharmacy, Jerusalem
    • Teaching Assistant.
  • 1986-1987 the Hebrew University, School of Pharmacy, Jerusalem
    • Instructor.
  • 1987-1988 the Hebrew University, School of Pharmacy, Jerusalem
    • Lecturer.
  • 1988-1993 the University of Ohio and the University of California (UCSB), USA
    • Assistant Professor.
  • 1994-2001 Eastern Pharmaceutical Company, Ramallah, Palestine.
    • CEO
  • 2005-2010 Al-Quds University, School of Pharmacy, Jerusalem, Palestine.
    • Associate Professor and Dean.
  • 2010-2012 Al-Quds University, School of Pharmacy, Jerusalem, Palestine.
    • Professor and Dean.
  • 2012-Present Al-Quds University, School of Pharmacy, Jerusalem, Palestine.
    • Professor and Promotion Committee Member.
  • 2010-Present Al-Quds University, Jerusalem, Palestine.
  • Palestine Coordinator in International PhD Programme entitled: “BioEcoSystems and BioTechnology”
  • (Countries participate: Italy, Spain, France, Greece, Poland and Egypt).
  • 2013-Present Basilicata University, College of Science, Potenza, Italy.
    • Adjunct Professor.
  • 2013-Present Al-Quds University, School of Pharmacy, Jerusalem, Palestine.
    • Distinguished Professor.

Teaching Experience

  • Medicinal Chemistry 1 (for pharmacy students at Toledo University, OH, USA and Al-Quds University, Palestine).
  • Medicinal Chemistry 2 (for pharmacy students at Toledo University, OH, USA and Al-Quds University, Palestine).
  • Advanced Medicinal Chemistry (for pharmacy master students at Al-Quds University, Palestine).
  • Drug Design (for pharmacy master students at Al-Quds University, Palestine and biotechnology PhD students at Basilicata University, Potenza, Italy).
  • Instrumental Analysis (for pharmacy and chemistry students, Toledo University, OH, USA).
  • Pharmacopial Analysis (for pharmacy students at Toledo University, OH, USA at Al-Quds University, Palestine).
  • Organic Chemistry 1 (for pharmacy and chemistry students, Toledo University, OH, USA and Al-Quds University, Palestine).
  • Organic Chemistry 2 (for pharmacy and chemistry students, Toledo University, OH, USA and Al-Quds University, Palestine).
  • General Chemistry (for pharmacy and chemistry students, Toledo University, OH, USA).
  • Industrial Pharmacy (for pharmacy students, Al-Quds University, Palestine).
  • Pharmaceutics 1 (for pharmacy students, Al-Quds University, Palestine).
  • Pharmaceutics 2 (for pharmacy students, Al-Quds University, Palestine).
  • Pharmaceutical Technology (for pharmacy students, Al-Quds University, Palestine).
  • Over the Counter Drugs (OTC) (for pharmacy students, Al-Quds University, Palestine).
  • Biochemistry 1 (for pharmacy and nursing students, Toledo University, OH, USA).

Research Interest

  • Design, synthesis, characterization and in vitro and in vivo kinetics of pro-prodrug systems to be used for the delivery for certain drugs that have poor water solubility or/and have low bioavailability using ab initio, DFT, semiempirical, molecular mechanics as well as molecular dynamics and conformational dynamics methods.
  • Design and synthesis of linkers to be used for masking bitter taste of drugs that contain a hydroxyl or amine groups (antimalarial, anti-hypertension, anti-bleeding, antibacterial and anticancer drugs) using DFT calculation methods.
  • Design and synthesis of bitter taste antagonists for inactivation of the bitter taste receptor 14.
  • Pharmaceuticals removal from wastewater using clay micelle complex, hollow fiber, spiral wounds, charcoal and other adsorbents.
  • Pharmaceuticals removal from wastewater using photodegradation methods such as light/TiO2.
  • Stability of Pharmaceuticals in wastewater and isolation and characterization of degradation products (metabolites).

Awards

  • Hadassa Medical Award (Jerusalem)-1983
  • Distinguished Scientist (Santa Barbara, USA)-1992
  • Distinguished Professor of Pharmaceutical Sciences (Jerusalem-Palestine)-2013

Selected publications

Citation Indices

  • h-index 25
  • i10-index 55
  • Total citations 1591

Books

1. Karaman R. Editor, “Prodrugs Design – A New Era” Nova Science Publishers, NY, USA, 2014, pp 1-278.

2. Karaman R. Editor, “Commonly Used Drugs-Uses, Side Effects, Bioavailability and Approaches to Improve It” Nova Science Publishers, NY, USA, 2014, pp 1-284.

Chapters in a Book

1. Karaman R. “Prodrugs for Masking the Bitter Taste of Drugs” Chapter 12 in Application of Nanotechnology in Drug Delivery, Editor: Ali Demir Sezer, InTech - Open Access Publisher, 2014, pp 399-445.

2. Karaman R. “From Conventional Prodrugs to Prodrugs Designed By Molecular Orbital Methods” Chapter in Frontiers in Computational Chemistry, Bentham Publisher, 2014, 1-77.

3. Karaman R. “Prodrugs Design Based On Inter- And Intramolecular Processes” in “Prodrugs Design – A New Era”, Karaman R. (editor), Nova Science Publishers, NY, USA, 2014, p 1-76.

4. Abu-jaish A., Jumaa S., Karaman R. “Prodrugs Overview” in “Prodrugs Design – A New Era”, Karaman R. (editor), Nova Science Publishers, NY, USA, 2014, p 77-102.

5. Fattash B., Karaman R. “Chemical Approaches Used In Prodrugs Design” in “Prodrugs Design – A New Era”, Karaman R. (editor), Nova Science Publishers, NY, USA, 2014, p 103-138.

6. Bader M., Thawabteh A., Karaman R. “Targeted Prodrugs” in “Prodrugs Design – A New Era”, Karaman R. (editor), Nova Science Publishers, NY, USA, 2014, p 139-176.

7. Habbabeh N., Karaman R. “Virus Directed Enzyme Prodrug Therapy (VDEPT)” in “Prodrugs Design – A New Era”, Karaman R. (editor), Nova Science Publishers, NY, USA, 2014, p 177-210.

8. Sirhan J., Karaman R. “GENE DIRECTED ENZYME PRODRUG THERAPY (GDEPT)” in “Prodrugs Design – A New Era”, Karaman R. (editor), Nova Science Publishers, NY, USA, 2014, p 210-232.

9. Amly W., Karaman R. “Antibody Directed Enzyme Prodrug Therapy (ADEPT) - A Promising Cancer Therapy Approach ” in “Prodrugs Design – A New Era”, Karaman R. (editor), Nova Science Publishers, NY, USA, 2014, p 233-278.

10. Karaman R. “Antimalarial Atovaquone Prodrugs Based on Enzyme M Odels - Molecular Orbital Calculations Approach” in Antimalarial Drug Research and Development, 2013, pp 1-67, Nova Science Publishers, NY, USA.

11. Hejaz H., Karaman R. “Drugs Overview” in Common Used Drugs - Uses, Side Effects, Bioavailability and Approaches to Improve It, Karaman, R. (editor) 2015, pp 1-40, Nova Science Publishers, NY, USA.

12. Jumaa S., Karaman R. “Antibiotics” in Common Used Drugs - Uses, Side Effects, Bioavailability and Approaches to Improve It, Karaman, R. (editor) 2015, pp 41-73, Nova Science Publishers, NY, USA.

13. Salah S., Awadallah, Karaman R. “Pain Killers” in Common Used Drugs - Uses, Side Effects, Bioavailability and Approaches to Improve It, Karaman, R. (editor) 2015, pp 75-129, Nova Science Publishers, NY, USA.

14. Amly W., Karaman R. “Lipid Lowering Medications- Uses, Side Effects, Pharmacokinetic Properties and Approaches to Improve Bioavailability ” in Common Used Drugs - Uses, Side Effects, Bioavailability and Approaches to Improve It, Karaman, R. (editor) 2015, pp 131-172, Nova Science Publishers, NY, USA.

15. Qtait A., Karaman R. “Antihyperglycemic Drugs” in Common Used Drugs - Uses, Side Effects, Bioavailability and Approaches to Improve It, Karaman, R. (editor) 2015, pp 173-200, Nova Science Publishers, NY, USA.

16. Ghareeb H., Karaman R. “Anti-hemorrhagic Agents” in Common Used Drugs - Uses, Side Effects, Bioavailability and Approaches to Improve It, Karaman, R. (editor) 2015, pp 201-217, Nova Science Publishers, NY, USA.

17. Khawaja Y., Karaman R. “Osteoporosis Drugs” in Common Used Drugs - Uses, Side Effects, Bioavailability and Approaches to Improve It, Karaman, R. (editor) 2015, pp 219-247, Nova Science Publishers, NY, USA.

18. Bader M., Karaman R. “Fumaric Acid Esters as a Treatment for Psoriasis and Multiple Sclerosis” in Common Used Drugs - Uses, Side Effects, Bioavailability and Approaches to Improve It, Karaman, R. (editor) 2015, pp 249-261, Nova Science Publishers, NY, USA.

Peer Reviewed Papers

1. Breuer E., Karaman R., Goldblum A. "A Novel Base-Catalyzed Fragmentation of Aliphatic Acylphosphonates" Phosphorus and Sulfur 1984, 21,119-120.

2. Breuer E., Karaman R., Leader H., Goldblum A. "Phosphorylation of Alcohols through the Acid Catalyzed Fragmentation of alpha-Oxyiminophosphonates" J. Chem. Soc., Chem. Commun. 1987, 671-672.

3. Breuer E., Karaman R., Leader H., Goldblum A., Moshe R. "Acylphosphonic Derivatives-New Precursors for Low Coordination Phosphorus Species" Phosphorus and Sulfur 1987,30,113-116.

4. Breuer E., Karaman R., Leader H., Goldblum A. 10 "Fragmentation of Acylphosphonates-New Precursors for Dicoordinated Phosphorus Species" Phosphorus and Sulfur 1987, 33, 61-63.

5. Karaman R., Leader H., Goldblum A., Breuer E. "Alkylation of Sulfonic Acids by Trialkyl Phosphites. A New Synthesis of Sulfonate Esters" Chem. and Ind. 1987, 857-858.

6. Breuer E., Karaman R., Gibson D.,Leader H., Goldblum A. "Alpha-Hydroxyiminophosphonic Acids. New types of Phosphorylating Agents through Monomeric Metaphosphates" J. Chem. Soc., Chem. Commun. 1988, 504- 06.

7. Breuer E., Karaman R., Goldblum A. "Sulphonic Acid-Induced Fragmentation of Dialkyl Acylphosphonates. Formation of alkyl Carboxylates and Alkyl Sulphonates" J. Chem. Soc. Perkin Trans. II 1988, 2029-2034.

8. Breuer E., Karaman R., Goldblum A., Gibson D., Leader H., Potter B. V. L., Cummins J. H. "Alpha-Oxyiminophosphonates: Chemical and Physical Properties. Reactions, Theoretical Calculations, and X-ray Crystal Structure of (E) and (Z)-Dimethyl alpha-Hydroxyiminobenzylphosphonates” J. Chem. Soc. Perkin Trans. I 1988, 3047-3057.

9. Karaman R., Goldblum A., Breuer E., Leader H. "Acylphosphonic Acids and Methyl Hydrogen Acylphosphonates: Physical and Chemical Properties and Theoretical Calculations" J. Chem. Soc. Perkin Trans. I 1989, 765-774.

10. Breuer E., Karaman R., Gibson D., Goldblum A. "Structure and Reactivity of 2-Hydroxyiminobenzyl-2-Ox0-4,4,5,5,tetrarmethyl[I,2,3]dioxaphospholanes” Phosphorus, Sulfur and Silica 1989, 41, 433-437.

11. Katzhendler J., Karaman R., Gibson D., Breuer E. "Fragmentation of Methyl Hydrogen alpha-Hydroxyiminophosphonates to Monomeric Methyl Metaphosphate: Stereochemistry and Mechanism" J. Chem. Soc. Perkin Trans II 1989, 589-594.

12. Gibson D., Karaman R. "Metal Complexes of alpha Hydroxyimino Phosphoric Acid Derivatives. Separation of the E and Z Isomers by Metal Chelation and the Preparation and Characterization of Copper Bis [(E)-(Alpha-Hydroxyiminobenzyl) Phosphonate] Water" lnorg. Chem. 1989, 28, 1928-1932.

13. Badejo I. T., Karaman R., Lee N. W. 1., Lutz E. C., Mamanta M.T., Fry J. L. "Syntheses of 9-Cyclohepta-2,4,6-trien-I-yt-9H-xanthen-9-o1 and Related Alcohols by a Novel Ump lung Method” J. Chem. Soc., Chem. Commun. 1989, 566-567.

14. Karaman R., Badejo I. T., Fry J. L. "Facile decomposition of 9-Substituted-9-xanthhydrols in Basic Media. Dependence of Reaction Behavior on Structure, and Metal Ion" J. Am. Chem. Soc. 1989, 111, 6450-6451.

15. Karaman R., Fry J. L. "Deoxygenation/Reduction of Aromatic Esters, Alpha-Diketones, Acyloins, and Epoxides to the Corresponding Bibenzyl Products with Lithium 4,4' –di-t- Butylbiphenyl Radical Anion" Tetrahedron Lett. 1989, 30, 4931-4934.

16. Karaman R., Fry J. L. "Electron Transfer Reactions of Aliphatic Esters to the Corresponding Aliphatic Ketones by Lithium 4,4'di-t-Butybiphenyl Radical Anion" Tetrahedron Lett. 1989, 30, 4935-4938.

17. Badejo I. T., Karaman R., Fry J. L. "Unstable Compounds, Synthesis and Experimental and Computational Study of the Chemical Behavior of 9-[1-(2, 4, 6-Cycloheptatrienyl)]-9- Xanthhydrol." J. Org. Chem. 1989, 54, 4591-4596.

18. Gibson D., Karaman R. "Metal Complexes of alpha-Hydroxyiminophosphonic Acid Derivatives.Preparation and Crystal Structures of the Ca and Cd Complexes of (E)-alpha. Hydroxyiminobenzylphosphonate" J. Chem. Soc. Dalton Trans. 1989, 1911-1914.

19. Breuer E., Karaman R., Goldblum A., Gibson D., Leader H., Potter B.V.L., Cummins J. H., Harkin S. A., Jones R. H., Tapolczay D. J., Thomas E. J.” Corrigendum” J. Chem. Soc., Perkin Trans. 1, 1989, 1367-1367

20. Karaman R., Fry J. L. "A Novel Synthesis of Aromatic Alpha-Diketones from Electron Transfer Reactions of Aromatic Acids with either Lithium 4,4' -di-t-Butylbiphcny1 Radical Anion or Lithium Metal" Tetrahedron Lett. 1989, 30, 6267-6270.

21. Karaman R., Fry J. L. "A Novel N-Dealkylation Reaction of N, N-Dialkylarylcarboxamides Promoted by Electron Transfer from Alkali Metals" Tetrahedron Lett. 1990. 31, 941-944.

22. Karaman R., Huang J. T. L., Fry J. L. "Correlation of the Acidity of Substituted Phenols, Anilines, and Benzoic Acids Calculated by MINDO, AM1, and PM3 with Hammett-type Substituent Constants" J. Comput. Chem. 1990, 11, 1009-1016.

23. Badejo I. T., Karaman R., Pinkerton A. A., Fry J. L. "Synthesis, Chemical and Physical Properties, X-ray Crystal Structure and Theoretical Calculations of 9-[1-(2, 4, 6-Cycloheptatrienylidene)-Xanthene" J. Org. Chem. 1990, 55, 4327-4332.

24. Karaman R., Kohlman D. T., Fry J. L. "Conversion of Aromatic Ketones, Benzyl Alcohol and Alkyl Aryl Ethers to Aromatic Hydrocarbons with Lithium 4,4'-Di-t-Butylbiphenyl Radical Anion" Tetrahedron Lett. 1990, 31, 6155-6158.

25. Karaman R., Huang J. T., Fry J. L. "Correlation of Hydride Affinities of Substituted Aromatic Carbocations and the Proton Affinities of Substituted Benzene Calculated by MNDO with Sigma+ Substituent Constants" J. Org. Chem. 1991, 56, 188-195.

26. Badejo I. T., Choi H., Hockensmith C. M., Karaman R., Pinkerton A. A., Fry J. L. "Unstable Compounds, Synthesis, Structure, and Experimental and Computational Carbocation Chemistry of 2-Cumyladamantan-2-o1 and its 6-Cr(Co)3 Complex” J. Org. Chem. 1991, 56, 4688-4695.

27. Karaman R., Huang J. T. L., Fry J. L. "Correlation of Single-Triplet Gap for Aryl Carbenes Calculated by MINDO/3, MNDO, AMI and PM3 with Hammet-type Substituent Constants" J. Comput. Chem. 1991, 12, 536-554.

28. Badejo I. T., Fry J. L., Karaman R., Nadkarni D., Pinkerton A. A. "9-Cyclohepta-2.4, 6-trien-l-yl-9H-Xanthen-9-ol. X-ray Crystal Structure and Computationally Optimized Structures Compared” Acta Cryst. 1991, C47, 1895-1898.

29. Karaman R., Bruice T. C. "Synthesis and Characterization of the First Water Soluble Porphyrin Dimer" J. Org. Chem. 1991, 56, 3470-3472.

30. Karaman R., Almarsson O., Bruice T. C. "A Molecular dynamics Approach to Symmetrical and Unsymmetrical Quadruply Closely-Interspaced Cofacial Porphyrin Dimers."

J. Org. Chem. 1992, 56, 1555-1559.

31. Karaman R., Almarsson O., Bruice T. C. “The Design, Synthesis and Characterization of a "Shopping Basket" Porphyrin Dimer. The First Example of Triply Bridged Closely-Interspaced Cofacial Porphyrin Dimer" J. Org. Chem. 1992, 57, 2169-2173.

32. Karaman R., Blasko A., Almarsson O., Arassasingham R., Bruice T. C. "Symmetrical and Unsymmetrical Quadruply Aza Bridged Closely-Interspaced Cofacial Bis-5,10,15,20-Tetra-Phenylporphyrins 2.Synthesis, Characterization and Conformational Effects of Solvents" J. Am. Chem. Soc. 1992, 114, 4889-4898.

33. Karaman R., Jeon S., Almarsson O., Bruice T. C.

"Symmetrical and Unsymmetrical Quadruply Aza Bridged Closely-Interspaced Cofacial Bis-5, 10, 15, 20-Tetra-Phenylporphyrins 3. Interplanar Distance, IH-NMR Chemical Shifts and Catalysis of the Electrochemical Reduction of Oxygen” J. Am. Chem. Soc. 1992, 114, 4898-4905.

34. Karaman R., Bruice T. C. "Unusual Behavior of meso-Substituted 5, 10, 15, 20- Tetraphenylporphyrin Diacid towards Oxygen Bronsted Bases” Inorg. Chem., 1992, 31, 2455-2459.

35. Almarsson O., Karaman R., Bruice T. C. "The Kinetic Importance of Conformations of Nicotinamide Adenine Dinucleotide in the Reactions of Dehydrogenase Enzymes"

J. Am. Chem. Soc. 1992, 114, 8702-8704.

36. Karaman R., He G-X. Chu F., Blasko A., Bruice T. C. "Opening of a Cyc1opropyl Ring in Diphenylcyclopropyl Alkenes Promoted by Electron Transfer from Potassium 4,4'-di-tert-Butylbiphenyl Radical Anion, and X-ray and Theoretical Calculations of the Structure of (Z)-l,2-Bis-(trans-2, trans-3-diphenylcyclopropyl)ethane. " J. Org. Chem. 1993, 58, 438-443. 

37. Jeon S., Almarsson O., Karaman R., Blasko A., Bruice T. C. "Symmetrical and Unsymmetrical Quadruply Aza Bridged Closely-Interspaced Cofacial Bis-5,10,15,20-Tetra-phenylporphyrins 4. Structure and Conformational Effects on Electrochemistry and the Catalysis of Electrochcmical Reductions of Dioxygen by Doubly, Triply and Quadruply N, N-Dimethylene Sulfonamide Bridged Dimeric Bis (Cobalt tetraphenylporphyrin)" Inorg. Chem. 1993, 32, 2562-2569.

38. Breuer E., Karaman R., Zaher H., Katz E. "Synthesis of some Acylphosphonates Thiosemicarbazones and Evaluation of their Antiviral Activity" Drug Design and Discovery 1994, 11, 39-44.

39. KatzhendIer J., Ringel I., Karaman R., Zaher H.. Breuer E. "Acylphosphonate Hemiketals-Formation Rate and Equilibrium: The Electron Withdrawing Effect of Dimethoxyphenyl Group" J. Chem.Soc. Perkins.Trans. 2 1997, 341-349.

40. Karaman R. “Analysis of Menger’s System” Tetrahedron Lett. 2008, 49, 5998-6002.

41. Karaman R. “A New Mathematical Equation Relating Activation Energy to Bond Angle and Distance: A Key for Understanding the Role of Acceleration in Lactonization of the Trimethyl Lock System” Bioorganic Chemistry 2009, 37, 11-25.

42. Karaman R. “Revaluation of Bruice’s Proximity Orientation” Tetrahedron Lett. 2009, 50, 452-458.

43. Karaman R. ”Accelerations in the Lactonization of Trimethyl Lock Systems are Due to Proximity Orientation and not to Strain Effects” Research Letters in Org. Chem. (2009) doi: 10.1155/2009/240253.

44. Karaman R.” Cleavage of Menger’s Aliphatic Amide: A model for peptidase enzyme solely explained by proximity orientation in intramolecular proton transfer” Journal of Molecular Structure (THEOCHEM) 2009, 910, 27-33.

45. Karaman R. “The gem-disubstituent effect- a computational study that exposes the relevance of existing theoretical models” Tetrahedron Lett. 2009, 50, 6083-6087. 

46. Karaman R. “Analyzing Kirby’s amine olefin – a model for amino-acid ammonia lyases” Tetrahedron Lett. 2009, 50, 7304-7309.

47. Karaman R. “The Effective Molarity (EM) Puzzle in Proton Transfer Reactions” Bioorganic Chemistry 2009, 37,106-110.

48. Karaman R.”Effects of substitution on the effective molarity (EM) for five membered ring-closure reactions- a computational approach” Journal of Molecular Structure (THEOCHEM) 2010, 939, 69-74.

49. Karaman R. “The Effective Molarity (EM) Puzzle in Intramolecular Ring-Closing Reactions” Journal of Molecular Structure (THEOCHEM) 2010, 940, 70-75.

50. Karaman R. “The efficiency of proton transfer in Kirby's enzyme model, a computational approach” Tetrahedron Lett. 2010, 51, 2130-2135.

51. Menger F. M., Karaman R.”A Singularity Model for Chemical Reactivity” Eur. J. Chem. 2010, 16, 1420-1427.

52. Karaman R. “The Effective Molarity (EM) – a Computational Approach” Bioorganic Chemistry 2010, 38, 165-172.

53. Menger F. M., Karaman R.”A Singularity Model for Chemical Reactivity” ChemInform Abstract 2010: DOI: 10.1002/chin.201018275.

54. Karaman R. “Proximity vs. Strain in Ring-Closing Reactions of Bifunctional Chain Molecules- a Computational Approach” J. Mol. Phys. 2010, 108, 1723-1730.

55. Karaman R., Alfalah S. “Multi Transition States in SN2 Intramolecular Reactions” Int. Rev. Biophys. Science 2010, 1, 14-23.

56. Karaman R., Pascal R. “A Computational Analysis of Intramolecularity in Proton Transfer Reactions” Org & Bimol. Chem. 2010, 8, 5174-5178. 

57. Karaman R., Hallak H. “Computer-assisted design of pro-drugs for antimalarial atovaquone ” Chem. Biol. Drug Design 2010, 76, 350-360.

58. Karaman R. “A General Equation Correlating Intramolecular Rates with Attack" Parameters: Distance and Angle” Tetrahedron Lett. 2010, 51, 5185-5190.

59. Karaman R., Menger, F. “Electrostatic Effects on the Energetics and Geometry of a Cyanine Dye” Journal of Molecular Structure (THEOCHEM) 2010, 959, 87-91.

60. Karaman R. “Prodrugs of Aza Nucleosides Based on Proton Transfer Reactions” J. Comput. Mol. Des. 2010, 24, 961-970.

61. Karaman R.”Analyzing Kemp’s Amides- a Model for Amidase Enzymes” Journal of Computational and Theoretical Chemistry 2011, 963, 427-434.

62. Khamis M., Karaman R., Ayyash F., Qtait A., Deeb O., Manassra A. “Efficiency of Advanced Membrane Wastewater Treatment Plant towards Removal of Aspirin, Salicylic Acid, Paracetamol and p-Aminophenol” Journal of Environmental Science & Engineering 2011,5, 121-137.

63. Karaman R. “Analyzing the efficiency of proton transfer to carbon in Kirby’s enzyme model- a computational approach” Tetrahedron Lett 2011, 52, 699-704.

64. Karaman R. “Computational aided design for dopamine prodrugs based on novel chemical approach

” Chem. Biol. Drug Design 2011, 78, 853-863.

65. Karaman R. ”Accelerations in the Lactonization of Trimethyl Lock Systems are Due to Proximity Orientation and not to Strain Effects” in Organic Chemistry: Structure and Mechanisms; Editor Harold Henry; Apple Academic Press Inc. pp.109-120, 2011.

66. Hejaz, H., Karaman R., Khamis M. “Computer-Assisted Design for Paracetamol Masking Bitter Taste Prodrugs” Journal of Molecular Modeling 2012, 18, 103-114.

67. Khamis M., Karaman R., Qurie M., Abbadi J., Nusseibeh S., Manassra A., Nir S. “Performance of micelle-clay filters for removing pollutants and bacteria from tertiary treated 17 wastewater” Journal of Environmental Science and Engineering A 2012, 1, 160-168.

68. Karaman R., Menger F. M. “Proton Shuffling in Acid/Base Catalyzed Enolizations. A Computational Study ” J. Phys. Org. Chem. 2012, 25, 1336-1342.

69. Karaman R. “The role of proximity orientation in intramolecular proton transfer reactions” Journal of Computational and Theoretical Chemistry 2011, 966, 311-321.

70. Karaman R., Khamis M., Qurie M., Halabieh R., Makharzeh I., Mannassra A., Nir S., Nasser A., Bufo S.A., “Removal of Diclofenac Potassium from Wastewater Using Clay-Micelle Complex” Journal of Environmental Technology 2012, 33(11), 1279-1287.

71. Karaman R. “Analyzing the efficiency in intramolecular amide hydrolysis of Kirby's N-alkylmaleamic acids - A computational approach” Journal of Computational and Theoretical Chemistry 2011, 974, 133-142.

72. Karaman R., Dajani K.K., Hallak H. “Computer-Assisted Design for atenolol Prodrugs for the Use in Aqueous Formulations” Journal of Molecular Modeling 2012,18, 1523–1540.

73. Karaman R. “Exploring the Mechanism for the Amine-Catalyzed Isomerization of Dimethyl Maleate. A computational Study” Tetrahedron Lett. 2012, 52, 6288-6292.

74. Karaman R., Dajani K.K., Qtait A., Khamis M. “Prodrugs of Acyclovir - A Computational Approach” Chemical Biology and Drug Design, 2012, 79, 819-834.

75. Karaman R., Bufo S. A., Scrano L., Hallak H. “The mechanism of the amine-catalyzed isomerization of dialkyl maleates. A computational study” J. Mol. Phys. 2012, 110, 467-482.

76. Karaman R.” Exploring the unexpected pyridine- and 4,4'-bipyridine-catalyzed isomerization of maleic acid. A DFT approach”. Journal of Computational and Theoretical Chemistry 2012, 988, 63-74.

77. Abbadi J., Karaman R., Khamis M., Saleh R.,Nuseibeh, S.,Qurie M., Bufo, S.A. “Microbial Removal from Secondary Treated Wastewater Using a Consequent System of Ultrafiltration (Hollow fiber and Spiral Wound) and Reverse Osmosis System” Journal of Environmental Science & Engineering A 1 2012,853-869.

78. Dahan A., Khamis M., Agbaria R., Karaman R. “Targeted Prodrugs in Oral Drug Delivery: The Modern Molecular Biopharmaceutical Approach” Expert Opinion on Drug Delivery 2012, 9, 1001-1013.

79. Khalaf S., Al-Rimawi F., Khamis M., Zimmerman D., Shuali U., Nir S., Bufo S.A., Scrano L., Karaman R., “Efficiency of membrane technology, activated charcoal, and a clay micelle complex for removal of the acidic pharmaceutical Ibuprofen” Journal of Environmental Science & Health Part B 2013,48, 814-821. 80. Karaman R. “The Future of Prodrugs designed by Computational Chemistry” Journal of Drug Designing, 2012, 1:e103. doi:10.4172/ddo.1000e103.

81. Karaman R., Dokmak G., Bader M.,Hallak, H., Khamis M., Scrano L., Bufo S. A. “Prodrugs of fumarate esters for the treatment of psoriasis and multiple sclerosis (MS)- A computational approach” J. Molecular Modeling. 2013, 19, 439-452.

82. Karaman R. “Computationally Designed Prodrugs for Masking the Bitter Taste of Drugs” Journal of Drug Designing, 2012, 1:e106. doi:10.4172/2169-0138.1000e106.

83. Khalaf S., Al-Rimawi F., Khamis M., Nir S., Bufo S.A., Scrano L., Karaman R., “Efficiency of membrane technology, activated charcoal, and a micelle-clay complex for removal of the acidic pharmaceutical mefenamic acid” Journal of Environmental Science & Health Part A 2013, 48, 1655–1662.

84. Qurie M.,Khamis M., Manassra A., Ayyad I., Nir S., Scrano L., Bufo S.A., Karaman R., “Removal of Cr(VI) from aqueous solution using micelle-clay complex” The Scientific World Journal 2013, Volume 2013, Article ID 942703, 7 pages.

85. Qurie M.,Khamis M., Malek F., Nir S., Scrano L., Bufo S.A., Karaman R., “Efficiency of advanced membrane wastewater treatment plant and micelle-clay complex towards removal of Naproxen ” Clean Soil, Air and Water Journal 2013, 41 (9999), 1–7. DOI: 10.1002/clen.201300179.

86. Ghanem M., Karaman R., Hallak H., Abu-Lafi S., “Validated HPLC Method to Simultaneously Determine Amprolium Hydrochloride, Sulfaquinoxaline Sodium and Vitamin K3 in A.S.K Powder on ZIC-HILIC Column” Journal of Pharmaceutica Analytica Acta 2012, 3:168. Doi: 10.4172/2153-2435.1000168.

87. Karaman R.,Khamis M., Abbadi J., Qurie M.,Ayyad I., Ayyash F., Hamarsheh O., Yaqmour R., Amro A., Nir S., Bufo S.A., Scrano L. “Biodegradation of Paracetamol By Activated Sludge and Their Removal Along With Their Metabolites By A Clay Micelle Complex, Reverse Osmosis And Activated Charcoal ” Journal of Environmental Science & Technology 2012, submitted.

88. Karaman R. “Computationally Designed Enzyme Models to Replace Natural Enzymes in Prodrug Approaches” Journal of Drug Designing, 2012, 1:e111. Doi: 10.4172/2169- 0138.1000e111.

89. Karaman R. “Prodrugs for Masking Bitter Taste of Antibacterial Drugs - A Computational Approach” J. Molecular Modeling. 2013, 19, 2399–2412.

90. Karaman R., Karaman D., Ziadeh I. “Computationally Designed Phenylephrine Prodrugs- A Model for Enhancing Bioavailability” J. Molecular Physics 2013, 111(21), 3249-3264.

91. Karaman R., Fattash B., Mecca G., Bader M. “Computationally Designed Atovaquone Prodrugs Based on Bruice’s Enzyme Model” Current Computer Aided Drug design 2014, 10(1):15-27. DOI: 10.2174/15734099113096660049.

92. Karaman R. “Prodrugs Design by Computation Methods- A New Era” Journal of Drug Designing 2013, 2: e113. doi:10.4172/2169-0138.1000e113.

93. Karaman R., Fattash B., Qtait A., “The Future of Prodrugs - Design By Quantum Mechanics Methods” Expert Opinion on Drug Delivery 2013, 10(5), 713-729.

94. Sulaiman S., Khamis M.,, Nir S., Lelario F., Scrano L., Bufo S.A., Karaman R. “Stability and Removal of 20 Dexamethasone Sodium Phosphate from Wastewater Using Different Techniques ” Journal of Environmental Technology 2014, 35(15), 1945-1955.

95. Sulaiman S., Scrano L., Bufo S.A., Karaman R. “Seasonal and spatial variation in the monitoring parameters of Zomar Stream/ Palestine during 2010 Journal of Environmental Science & Engineering B1 2012, 499-509.

96. Qurie M., Abbadi J., Scrano L., Mecca G., Bufo S.A., Khamis M. and Karaman R. “Inland Treatment of the Brine Generated from Reverse Osmosis Advanced Membrane Wastewater Treatment Plant using Epuvalisation System” Int. J. Mol. Sci. 2013, 14, 13808-13825; doi:10.3390/ijms140713808.

97. Karaman R., Ghareeb H., Dajani K.K., Scrano L., Hallak, H., Abu-Lafi S., Bufo S. A. “Design, synthesis and in-vitro kinetic study of tranexamic acid prodrugs for the treatment of bleeding conditions” J. Molecular Aided Computer Design 2013, 27(7), 615-635.

98. Sulaiman S., Khamis M.,, Nir S., Lelario F., Scrano L., Bufo S.A., Karaman R. “Diazepam stability in Wastewater and removal by Advanced Membranes Technology, Activated Carbon and Micelle- Clay Complex” Journal of desalination and Water Treatment 2014, DOI: 10.1080/19443994.2014.981225.

99. Karaman R., Amly W., Scrano L., Mecca G., Bufo S. A. “Computationally Designed Prodrugs of Statins Based on Kirby’s Enzyme Model ”Journal of Molecular Modeling 2013, 19(9), 3969-3982.

100. Karaman R. “Prodrugs Design Based on Inter- and Intra-molecular Chemical Processes” Journal of Chemical Biology & Drug Design, 2013, 82, 643-668.

101. Karaman R. “Prodrug Design vs. Drug Design” Journal of Drug Designing, 2013, 2: e114. doi:10.4172/2169-0138.1000e114.

102. Karaman R. “The Prodrug Naming Dilemma” Journal of Drug Designing, 2013, Drug Des 2: e115. doi:10.4172/2169-0138.1000e115.

103. Karaman R. “Antimalarial Atovaquone Prodrugs Based on Enzyme Models - Molecular Orbital Calculations Approach” in Antimalarial Drug Research and Development, Eds Banet A.C. & Brasier P.E. Nova Science Publishers, NY, USA 2013 pp 1-67.

104. Karaman R. “A Solution to Aversive Tasting Drugs for Pediatric and Geriatric Patients” Journal of Drug Designing, 2013, Drug Des, DOI:10.4172/2169-0138.1000e116.

105. Karaman R., Qtait A., Dajani K.K., Abu-Lafi S. “Design and Synthesis of an Aqueous Stable Atenolol Prodrug” The Scientific World Journal 2014, Volume 2014 (2014), Article ID 248651, 13 pages. http://dx.doi.org/10.1155/2014/248651.

106. Haddad M.’ Khamis A., Dakiky M., Manassra A., Qurie M., Karaman R. “The Response of Chickpea Cultivars to Irrigation with Treated Wastewater ” Journal of Earth Science & Engineering 2013, 3, 603-612.

107. Karaman R. “Enzyme Models- Mechanistic Investigation” Trends in Organic Chemistry, 2014, in press.

108. Karaman R. “Prodrugs for Masking the Bitter Taste of Drugs” Chapter 12 in Application of Nanotechnology in Drug Delivery,, Editor: Ali Demir Sezer,, nTech - Open Access Publisher,, 2014, pp 399-445.

109. Karaman R. “From Conventional Prodrugs to Prodrugs Designed by Molecular Orbital Methods” Chapter in Frontiers in Computational Chemistry Vol. 2, Chapter 5, Editors: Zaheer-ul-Haq, J.D. Madura, Bentham Publisher, 2015, 187-249.

110. Karaman R. Editor, “Prodrugs Design – A New Era” Nova Publisher, USA, 2014, pp 1-278.

111. Karaman R. “Prodrugs Design Based On Inter- And Intramolecular Processes” in “Prodrugs Design – A New Era”, Karaman R. (editor), Nova Publisher, USA, 2014, p 1-76.

112. Abu-jaish A., Jumaa S., Karaman R. “Prodrugs Overview” in “Prodrugs Design – A New Era”, Karaman R. (editor), Nova Publisher, USA, 2014, p 77-102.

113. Fattash B., Karaman R. “Chemical Approaches Used In Prodrugs Design” in “Prodrugs Design – A New Era”, Karaman R. (editor), Nova Publisher, USA, 2014, p 103-138.

114. Bader M., Thawabteh A., Karaman R. “Targeted Prodrugs” in “Prodrugs Design – A New Era”, Karaman R. (editor), Nova Publisher, USA, 2014, p 139-176.

115. Habbabeh N., Karaman R. “Virus Directed Enzyme Prodrug Therapy (VDEPT)” in “Prodrugs Design – A New Era”, Karaman R. (editor), Nova Publisher, USA, 2014, p 177-210.

116. Sirhan J., Karaman R. “GENE DIRECTED ENZYME PRODRUG THERAPY (GDEPT)” in “Prodrugs Design – A New Era”, Karaman R. (editor), Nova Publisher, USA, 2014, p 210-232.

117. Amly W., Karaman R. “Antibody Directed Enzyme Prodrug Therapy (ADEPT) - A Promising Cancer Therapy Approach ” in “Prodrugs Design – A New Era”, Karaman R. (editor), Nova Publisher, USA, 2014, p 233-278.

118. Awwad A., Al-Rimawi F.,Dajani K.K., Khamis M.,, Nir S., Karaman R. “Removal of Amoxicillin and Cefuroxime Axetil by Advanced Membranes Technology, Activated Carbon and Micelle- Clay Complex ” Journal of Environmental Technology 2015, DOI: 10.1080/09593330.2015.1019935.

119. Karaman R. “Using Predrugs to Optimize Drug Candidates” Expert Opinion in Drug Discovery Journal, 2014, 9(12), 1405-1419.

120. Karaman R. “Prodrugs- Current and Future Drug Development Strategy” International Journal of Medical and Pharmaceutical Case Reports 2014, 1(2), 58-63.DOI: 10.9734/IJMPCR/2014/13183.

121. Scrano L., Khalaf S., Lelario F., Karaman R., Bufo S.A. “Efficiency of a photocatalysis process using TiO2 powder dispersion and TiO2 immobilized on glass slabs for the removal of ibuprofen from aquatic environment” Chemosphere, 2014, submitted.

122. Karaman R. “Novel Modified Bentonite-Montmorillonite and Activated Charcoal Complexes for Detoxification” International clinical toxicology Journal 2015, 2(2), 37-41.

123. Karaman R. “Design of Prodrugs to Replace Commonly Used Drugs Having Bitter Sensation” World Journal of Pharmaceutical Research 2015,4(2):49-58.

124. Karaman R. “Computationally Designed Prodrugs Based on Enzyme Models” Aperito Journal of Drug Designing and Pharmacol 2015, 2:111. http://dx.doi.org/10.14437/AJDDP-2-111.

125. Sulaiman S., Khamis M.,, Nir S., Lelario F., Scrano L., Bufo S.A., Karaman R. “Stability and Removal of Spironolactone from Wastewater ” Journal of Environmental Science & Health Part A 2015, in press.

126. Sulaiman S., Khamis M.,, Nir S., Lelario F., Scrano L., Bufo S.A., Karaman R. “Stability and Removal of Atorvastatin, Rosuvastatin and Simvastatin from Wastewater

” Journal of Environmental Technology 2015, Submitted.

127. Hejaz H., Karaman R. “Drugs Overview” in Common Used Drugs - Uses, Side Effects, Bioavailability and Approaches to Improve It, Karaman, R. (editor) 2015, pp 1-40, Nova Science Publishers, NY, USA.

128. Jumaa S., Karaman R. “Antibiotics” in Common Used Drugs - Uses, Side Effects, Bioavailability and Approaches to Improve It, Karaman, R. (editor) 2015, pp 41-73, Nova Science Publishers, NY, USA.

129. Salah S., Awadallah, Karaman R. “Pain Killers” in Common Used Drugs - Uses, Side Effects, Bioavailability and Approaches to Improve It, Karaman, R. (editor) 2015, pp 75-129, Nova Science Publishers, NY, USA.

130. Amly W., Karaman R. “Lipid Lowering Medications- Uses, Side Effects, Pharmacokinetic Properties and Approaches to Improve Bioavailability ” in Common Used Drugs - Uses, Side Effects, Bioavailability and Approaches to Improve It, Karaman, R. (editor) 2015, pp 131-172, Nova Science Publishers, NY, USA.

131. Qtait A., Karaman R. “Antihyperglycemic Drugs” in Common Used Drugs - Uses, Side Effects, Bioavailability and Approaches to Improve It, Karaman, R. (editor) 2015, pp 173-200, Nova Science Publishers, NY, USA.

132. Ghareeb H., Karaman R. “Anti-hemorrhagic Agents” in Common Used Drugs - Uses, Side Effects, Bioavailability and Approaches to Improve It, Karaman, R. (editor) 2015, pp 201-217, Nova Science Publishers, NY, USA.

133. Khawaja Y., Karaman R. “Osteoporosis Drugs” in Common Used Drugs - Uses, Side Effects, Bioavailability and Approaches to Improve It, Karaman, R. (editor) 2015, pp 219-247, Nova Science Publishers, NY, USA.

134. Bader M., Karaman R. “Fumaric Acid Esters as a Treatment for Psoriasis and Multiple Sclerosis” in Common Used Drugs - Uses, Side Effects, Bioavailability and Approaches to Improve It, Karaman, R. (editor) 2015, pp 249-261, Nova Science Publishers, NY, USA.

135. Karaman R. Editor, “Commonly Used Drugs-Uses, Side Effects, Bioavailability and Approaches to Improve It” Nova Science Publishers, NY, USA, 2014, pp 1-284.

136. Khawaja y., Karaman R. “A Novel Mathematical Equation For Calculating The Number of ATP Molecules Generated From Sugars In Cells” World Journal of Pharmaceutical Research 2015, 4(4):303-312.

137. Karaman R., Jumaa S., Awadallah H., Salah S., Khawaja Y. “Intramolecular Processes and Their Applications for a Design and Synthesis of Prodrugs” Current Organic Chemistry 2015, Submitted.

138. Awwad A., Al-Rimawi F., Khamis M., Nir S.,Thawabteh A., Khalaf S, Karaman R. “Removal of Amoxicillin and Cefuroxime axetil Using Membrane Technology, Activated Charcoal and Micelle-Clay Complex ” International Journal of Case Studies 2015, In press.

139. Ayyash F., Khamis M., Khalaf S., Thawabteh A.,Karaman R. “Removal of Aspirin, Salicylic Acid, Paracetamol and p-Aminophenol by Advanced Membrane technology Activated Charcoal and Clay Micelles Complex ” International Journal of Case Studies 2015, In press.

140. Khalaf S., Al-Rimawi F., Khamis M., Nir S., Scrano L., Bufo S. A.,Karaman R. “Efficiency of membrane technology, activated charcoal and a clay micelle complex for the removal of ibuprofen and mefenamic acid ” International Journal of Case Studies 2015, In press.

141. Sulaiman S., Khamis M., Nir S., Scrano L., Lelario F., Bufo S. A.,Karaman R. “Removal of organic pollutants from wastewater using different treatment technologies ” International Journal of Case Studies 2015, In press.

Papers Presented Before Scientific Meetings

1. Breuer E., Karaman R., Leader H., Goldblum A., Moshe R.

"Acylphosphonic Derivatives-New Precursors for Low Coordination Phosphorus Species.” X-International Conference on Phosphorus Chemistry, Bonn, Germany, Aug. 31 Sept. 6, 1986. Abstract A-3.

2. Breuer E., Karaman R., Leader H., Gibson D., Goldblum A.

"The Structure of alpha-Hydroxyiminophosphonates and their Reactivity in Phosphorylation.” Fifth European Symposium on Organic Chemistry (ESOC V), Jerusalem, Israel, Aug. 30-Sept. 3, 1987.

3. Badejo I. T., Fry J. L., Karaman R. "The Chemistry of 9-[1-(2, 4, 6-cycloheptatrienyl}] Xanthene."

21st Central Regional Meeting of the American Chemical Society, Cleveland, Ohio, May 31-June 2, 1989. Abstract No. 279.

4. Badejo I.T., Karaman R., Pinkerton A. A., Fry J. L.

"Synthesis, Chemical and Physical Properties, X-ray Crystal Structure, and Theoretical Calculations of 9-[1-(2, 4, 6-cycloheptatrienylidene)] Xanthene.” 199th American Chemical Society National Meeting, Boston, Massachusetts, April 22-27, 1990. Abstract No. 20.

5. Badejo I. T., Karaman R., Pinkerton A, Fry J. L.

"Synthesis, Chemical and Physical Properties, X-ray Crystal Structure, and Theoretical Calculations of 9-[1-(2, 4, 6-cycloheptatrienylidene)] Xanthene.” Experimental and Computational Chemistry, a 60th Birthday Symposium, lnstitut Fur Chemie, HenkenstraBe 42, D-8520 Erlangen, Germany, April 25-27, 1990.

6. Karaman R., Fry J. L., Huang J.-T. L. “A Semiempirical Approach to Substituent Interactions in Aromatic Carbocations and Aromatic Anions." 22nd Central Regional Meeting of the American Chemical Society, Saginaw, Michigan. June 6-8, 1990.

7. Kohlman D., Fry J. L., Karaman R., Huang J.-T. L. “Electron Transfer in the Addition of Alkyl Halides to Xanthone Promoted by Lithium DBB Radical Anion.” 22nd Central Regional Meeting of the American Chemical Society, Saginaw, Michigan, USA, June 6-8, 1990.

8. Karaman R., Fry J. L., Huang J.-T. L. “A Semiempirical Approach to Substituent Interactions in Aromatic Carbocations and Aromatic Anions. “ 22nd Central Regional Meeting of the American Chemical Society, Saginaw, Michigan, USA, June 6-8, 1990.

9. Karaman R.”Hyroxyhydrocinnamic Acid System. A unique Chemical Entity for Providing Prodrugs for Variety of Drugs that are Limited to Certain Routes.”26th Pan Arab Conference and the 12th Jordanian Pharmacist Conference, Amman Jordan, April 10-12, 2008.

10. Karaman R. “A new Equation Relating Bond Angle and Distance to Reactions Rate.” 1st International Conference on Drug and Discovery, Dubai, February, 2008.

11. Karaman R. “the Trimethyl Lock System, the Best Candidate as a Pro-prodrug System.” The 4th Palestinian Chemistry Conference, Jerusalem, Palestine, April 14-15, 2008.

12.Karaman R., O. Deeb, F. Ayyash, A. Mannassra and M. Khamis “Efficiency of the membrane technology in terms of pharmaceutical removal from wastewater” Innovative Processes and Practices of Wastewater Treatment and reuse in the Mediterranean Region, Girona, Spain, 8-9 October, 2009.

13.Karaman R., “A Computational Approach for prodrug systems” The 2nd International Conference of Drug Discovery and Therapy, Dubai, UAE between 1-4 Feb. 2010.

14. Karaman R, “Programmable Pro Prodrug Systems” The 6th Palestinian Pharmacy Conference, Bethlehem, Palestine between 7-9 April 2010.

15.Karaman R, “Efficiency of the Membrane Technology in Terms of Pharmaceuticals Removal from Wastewater” 6th Conference on Pesticides and Related Organic Micro pollutants in the Environment, Matera, Italy Sep 5th-10th 2010.

16. Karaman R, “Efficiency of the Membrane Technology in Terms of Pharmaceuticals Removal from Wastewater” 1st United Arab Emirates Conference on Pure and Applied Chemistry, ECPAC11, March 1-3, 2011, American University of Sharjah, UAE.

17. Karaman R, “Design of prodrugs for some common diseases based on Proton Transfer Reactions ” 6Th Scientific Conference in Medicine, Convention Palace, Bethlehem, March 24-25, 2011, Bethlehem, Palestine.

18. Qurie M., Khamis M., Karaman R., Scrano L and Bufo S., Removal of organic pollutants from treated wastewater using micelle- clay fitters. XIV Symposium in Pesticide Chemistry. 30 Th August- 1st September 2011. Piacenza. Italy.

19. Qurie M., Khamis M., Karaman R., Fida M., Scrano L. and Bufo S.A., Efficiency of advanced wastewater treatment towards removal of naproxen and its degradation compounds. 7th MGPR International Symposium”Paolo Cabras”. 9-11 November 2011. Thessaloniki. Greece. (Poster).

20.Qurie M., Khamis M., Karaman R., Ayyad I., Manassra A. Scrano L, Bufo S.A , Removal of Cr(VI) from industrial wastewater using clay-micelle complex. 4th International Congress of the European Confederation of Soil Science Societies (ECSSS). 2-6 July 2012, Bari – Italy.

21. Karaman R., Khamis M., Rimawi F., Qurie M., Abbadi J., Malek F., Khalaf S., Nir S., Scrano L. and Bufo S.A. Efficiency of advanced membrane wastewater treatment technology coupled with activated carbon and clay micelles complexes towards removal of NSAID drugs. 4th International Congress of the European Confederation of Soil Science Societies (ECSSS). 2-6 July 2012, Bari –Italy.

22. Qurie M., Khamis M., Karaman R., Scrano L., Bufo S.A. Inland treatment of the Reverse Osmosis Brine generated from advanced membrane wastewater treatment plant using Epuvalisation System. 3ed Conference of Biotechnology Research and Applications. 20 October 2012. Jerusalem. Palestine.

23.Karaman R., Dokmak G., Ghareeb H. Design and synthesis of several novel prodrugs via mimicking enzymes catalysis , 26-28 April 2012, Amman, Jordan.

24. Karaman R., Hejaz H. Paracetamol Masking Bitter Taste Prodrugs- A Computational Approach. ISOT Conference 29th June 2012. Stockholm, Sweden

25. Levit A., Wiener A., Nowak S., Karaman R., Behrens M., Meyerhof W. and Niv M. Y. Computational spotlight on potential new agonists of hTAS2R14. ISOT Conference 29th June 2012. Stockholm, Sweden

26.Sulaiman S., Karaman R., Khamis M., Scrano L., Bufo S.A. Degradation and Removal of Dexamethasone Sodium Phosphate and Microbes Using Different Wastewater Treatment Technologies Including Adsorption on Activated Carbon and Clay- Micelles Complexes. 3rd Conference on biotechnology and Applications in Palestine, 20th October 2012. Jerusalem. Palestine (Poster).

27. Karaman R. Efficiency of advanced membrane wastewater

Treatment technology coupled with activated carbon and clay micelles complexes towards removal of NSAID drugs. Workshop for SANOFI Project Research on Removal of Pharmaceuticals from Wastewater, 19th September 2012. Larnaca, Cyprus.

28. Karaman R. Design and synthesis of several novel prodrugs via mimicking enzymes catalysis. International Conference and Exhibition on Computer Aided Drug Design & QSAR 28th October 2012. Chicago, Il, USA.

29.Qurie M., Khamis M., Karaman R., Scrano L., Bufo S.A., Nir S. Removal of Diclofenac Potassium from Wastewater Using Clay-Micelle Complex. Nonotechitaly 2011 23-25 November 2011.venice, Italy.

30. Karaman R, “Design and synthesis of several novel prodrugs via mimicking enzymes catalysis ”International Conference and Exhibition on Computer Aided Drug Design & QSAR, October 29-31, 2012, Chicago-North Shore, USA.

31. Saleh, S., Laura, S., Filomena, L., Shlomo, N., Sabino, A.B., Karaman, R. (2013, June). Photodegradation and photocatalysis of Diazepam in liquid phase. Poster presented at the 14th EuCheMS International Conference on Chemistry and the Environment (ICCE2013), Barcelona, Spain.

32. Saleh, S., Laura, S., Filomena, L., Shlomo, N., Sabino, A.B., Karaman, R. (2013, June). Photocatalytic degradation of Spironolactone by using Advanced Oxidation Processes (AOPs). Poster presented at the 14th EuCheMS International Conference on Chemistry and the Environment (ICCE 2013), Barcelona, Spain.

33. S. Khalaf , L. SCRANO,F. LELARIO, S. A. BUFO and R. KARAMAN. Efficiency of heterogeneous photo-catalysis (TiO2) for the removal of an acidic pharmaceutical from liquid phase: case study Diclofenac sodium. 3rd EUROPEAN CONFERENCE ON ENVIRONMENTAL APPLICATIONS OF ADVANCED OXIDATION PROCESS. ALMERIA (SPAIN), 27-30 OCTOBER 2013.

34. F. Lelario, L. Scrano, S. Khalaf, S. Sulaiman, R. Karaman, S.A. Bufo. LIQUID CHROMATOGRAPHY AND HIGH-RESOLUTION FOURIER TRANSFORM ION CYCLOTRON RESONANCE MASS SPECTROMETRY (LC/ESI-FT-ICR-MS) APPLIED TO THE IDENTIFICATION OF PHARMACEUTICAL PHOTODEGRADATION BYPRODUCTS. 4 MS-J-Day- I giovani e la spettrometria di massa 2013, Basilicata University, Potenza, Italy.

35. F. Lelario, L. Scrano, S. Khalaf, S. Sulaiman, R. Karaman, S.A. Bufo. Liquid chromatography mass spectrometry and high-resolution Fourier transform ion cyclotron resonance mass spectrometry (LC/ESI-FT-ICR-MS) for identifying photodegradation products of pharmaceuticals in the aquatic environment. 11th European Fourier Transform Mass Spectrometry Conference, Paris, April 22-25, 2014.

36. S. Khalaf, S. Sulaiman, R. Karaman, S.A. Bufo. Diffusion of nanotechnology based devices for water treatment and recycling. University Of Basilicata, Potenza, Italy, May 12th -16th, 2014.

37. S. KHALAF, L. SCRANO, F. LELARIO, R. KARAMAN and S. A. BUFO.Efficiency of a solar photocatalysis process using TiO2 powder dispersion and TiO2 immobilized on blue glass slabs for the removal of ibuprofen from aqueous

environments. 2nd International Conference of Recycling and Reuse, (R&R, 2014). Istanbul, Turkey, on June 4-6, 2014.

38. Alfalah S., Karaman R. Multi-transition states for SN2 reaction in intramolecular processes. Entropy in Biomolecular Systems. May 14, 2014 to May 17, 2014. Location : DACAM, Max F. Perutz Laboratories, University of Vienna, Dr. Bohrgasse 9, A-1030, Vienna, Austria

39. L Scrano, F Lelario, S Khalaf, S Sulaiman, R Karaman, S A Bufo, EFFICIENCY OF SOME PHARMACEUTICALS' REMOVAL FROM AQUEOUS ENVIRONMENTS BY USING PHOTODEGRADATION COUPLED WITH TiO2 POWDER DISPERSION AND TiO2 IMMOBILIZED ON BLUE GLASS SLABS. Pesticides 2014 - 8th European Conference on Pesticides and Related Organic Micropollutants in the Environment, 14th Symposium on the Chemistry and Fate of Modern Pesticides”, Ioannina, Greece, 18-21 September 2014, Ioannina, Greece; 09/2014. 40. S Sulaiman, L Scrano, F Lelario, S A Bufo, R Karaman, Removal of Naproxen in liquid phase by Using Advanced Oxidation Processes (AOPs). Recycling and Reuse, (R&R, 2014), Istanbul; 06/2014.

41. Mustafa Khamis & Rafik Karaman “ Application of Clay - Micelles Complexes for Removal of Pharmaceutical from Wastewater” the 2015 International Conference on Water, Energy and Environment (ICWEE 2015) taking place 24-26 March 2015, at the American University of Sharjah, Sharjah, UAE.

42. Rafik Karaman & Mustafa Khamis “Removal of Organic Micropollutants from Water by Applying Clay Composites” the 2015 International Conference on Water, Energy and Environment (ICWEE 2015) taking place 24-26 March 2015, at the American University of Sharjah, Sharjah, UAE.

Invited Lectures

  • Design and Synthesis of prodrugs for masking the bitter sensation of commonly used drugs, May 7, 2014, University of Basilicata, Potenza, Italy.
  • Computational Methods Used in Drugs and Pro-drugs Design, April 16, 2014, University of Basilicata, Potenza, Italy.
  • In Silico Design and Synthesis of Prodrug Systems Part 1, April 18, 2013, University of Basilicata, Potenza, Italy.
  • In Silico Design and Synthesis of Prodrug System Part 2, April 22, 2013, University of Basilicata, Potenza, Italy.
  • Computational Design and Synthesis of Pro-drug Systems, Part 3, May 20, 2013, University of Basilicata, Potenza, Italy.
  • Structure-Activity Relationship in the Assessment of Enzymatic Systems, Part 4, May 27, 2013, University of Basilicata, Potenza, Italy.
  • Design and Synthesis of Bitter Taste Antagonists, February 5, 2013, University of Basilicata, Potenza, Italy.
  • Removal of Pharmaceuticals from Waste Water: Isolation, Identification and Organic Reactions, February 14, 2013, University of Basilicata, Potenza, Italy.
  • Design and synthesis of several novel prodrugs via mimicking enzymes catalysis, September 16, 2012, Forschungszentrum Jülich GmbH (Jülich Research Centre), Germany.
  • Efficiency of advanced membrane wastewater treatment technology coupled with activated carbon and clay micelles complexes towards removal of NSAID drugs
  • September 18, 2012, Forschungszentrum Jülich GmbH (Jülich Research Centre), Germany.
  • Efficiency of the Membrane Technology in Terms of Pharmaceuticals Removal from Wastewater, Oct 19, 2010, University of Basilicata, Potenza, Italy.
  • Enzyme Models and Prodrug Systems- a Computational Approach, Feb 9, 2010, Potsdam University, Berlin, Germany.
  • Enzyme Models- a Computational Approach, November 18, 2009, the Hebrew University at Rehovot, Jerusalem, Israel.
  • Removal of Pharmaceuticals from Waste Water, May 10th-2009 Larnaca-Cyprus.
  • The Chemistry of Cofacial Porphyrin Dimers, May 12, 1994, the Hebrew University, Jerusalem, Israel.
  • Synthesis and Characterization of Cofacial Porphyrin Dimers, March 12, 1992, University of Southern California, CA, USA.
  • Synthesis and Characterization of Cofacial Porphyrin Dimers, March 12, 1992, Portland University, Portland, USA.
  • Acylphosphonic Acids as Antifungal Agents, March, 21, 1989, Boston University, MA, USA.
  • Physical and Chemical Properties of Acylphosphonic Acids and Their Oximino Derivatives, April 14, 1989, University of North Carolina, NC, USA.
  • Synthesis and Characterization of Acylphosphonic Acids, April 6, 1989, Potsdam University, NY, USA.
  • Acylphosphonic Acids and Their Oximino Derivatives, May 5, 1989, University of Toledo, OH, USA.
  • Synthesis and Characterization of Oximino-acylphosphonic Acids, May 26, 1989, University of South Dakota, SD, USA.
  • Synthesis and Characterization of Acylphosphonic Acids, May 28, 1989, University of Pittsburg, PH, USA.

Membership

Editorial Membership

  • Lead Guest Editor Organic Chemistry International Special Issue on “Biologically Relevant Computational Chemistry - New methods and applications”. 
  • Editorial board of Orphan Drugs: Research and Reviews. 
  • Editorial board of Drug designing Journal.
  • Editorial board of European Journal of Biophysics. 
  • Editorial board of American Journal of Pharmacological Sciences. 
  • Academic Editor of British Journal of Pharmaceutical Research. 
  • Editorial Board in Journal of Advanced Pharmaceutical Science and Technology. 
  • Editorial Board in Journal of New Developments in Chemistry. 
  • Editorial Board in International Journal of Pharmacy Research. 
  • Editorial Board in Journal BPJ0000205 - BIOINFO Pharmaceutical Biotechnology. 
  • Editorial Board in Academia Research. 
  • Editorial Board in Journal of Drug Design and Research.
  • Editorial Board in Journal of Analytical and Pharmaceutical Chemistry. 
  • Editorial Board in Journal of Biochemistry and Molecular Biology Research. 
  • Editorial Board in International Journal of Clinical Toxicology. 
  • Editorial Board in Pharmacology & Drug Designing Journal. 
  • Editorial Board in World journal of pharmaceutical research (WJPR.
  • Editorial Board in Journal of Medicinal Chemistry and Research (Peertechz Journals).
  • Editorial Board in Journal of Pharmaceutical Sciences and Development Research (Peertechz Journals. 19-Editorial Board in European Journal of Pharmaceutical and Medical Research.

Reviewer Membership

  • International Research Journal of Pharmacy and Pharmacology.
  • Journal of Molecular Modeling.
  • Journal of Research in Environmental Science and Toxicology (JREST).
  • Journal of Therapeutic Delivery. 
  • Bulletin of the Chemical Society of Ethiopia.
  • Journal of Modern Chemistry. 
  • Computational Biology and Bioinformatics.
  • African Journal of Internal Medicine. 
  • CLEAN-Soil, Air, Water Journal. 
  • The American Journal of Pharmacological Sciences. 
  • African Journal of Pharmacy and Pharmacological Research.
  • Peak Journal of Pharmacy and Pharmaceutical Sciences.
  • Journal of Environmental Science & Health Part B.
  • International Journal of Educational research and Review (IJERR.

Societies Membership

  • American Chemical Society
  • Sigma XI
  • Palestinian Health Ministry- GMP Committee
  • Palestinian Pharmacists Web (Editorial Board Member)
  • Arab Israeli Scientists Committee(Member)
  • International Doctorate Program-Italy (Committee Member)